Our lab is driven to understand how molecular mechanisms drive disease in patients with ALS/FTD. Our primary research goal is to identify the molecular cascade of pathogenic events that are initiated in these debilitating diseases in efforts to develop efficacious therapeutic strategies.
Neuronal activity-dependent gene dysregulation in C9orf72 i3Neuronal models of ALS/FTD pathogenesis Layla Ghaffari et al. 2025. AJP – Cell Physiology
Our recent study using iPSC-derived cortical neurons reveals how neuronal activity drives gene dysregulation in C9ORF72-linked ALS/FTD. We uncover synaptic dysfunction, peroxisomal dysregulation, and NPAS4-linked transcriptional shifts, highlighting key disease-modifying pathways. Explore our research and generate your own discoveries using our interactive dataset included in the link in the article.
