Aaron Haeusler Lab

Identifying neurodegenerative

mechanisms and interventions for ALS and FTD

Research

Our lab is driven to understand how molecular mechanisms drive disease in patients with ALS/FTD. Our primary research goal is to identify the molecular cascade of pathogenic events that are initiated in these debilitating diseases in efforts to develop efficacious therapeutic strategies.

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Our Latest Publications

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
Cicardi, M et al. 2024. Commun. Biol.

The nuclear import receptor Kapβ2 interacts with and modulates the neurotoxicity of poly(GR) in C9orf72-linked ALS/FTD. By interacting with poly(GR), Kapβ2 significantly improves neuronal survival, underscoring its potential as a therapeutic target to mitigate neurodegeneration. This discovery opens new avenues for research into ALS/FTD treatment strategies focused on enhancing Kapβ2 expression levels.