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Aaron Haeusler Lab

Identifying neurodegenerative

mechanisms and interventions for ALS and FTD

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Research

Our lab is driven to understand how molecular mechanisms drive disease in patients with ALS/FTD. Our primary research goal is to identify the molecular cascade of pathogenic events that are initiated in these debilitating diseases in efforts to develop efficacious therapeutic strategies.

Our Latest Publications

The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
Cicardi, M et al. 2024. Commun. Biol.

The nuclear import receptor Kapβ2 interacts with and modulates the neurotoxicity of poly(GR) in C9orf72-linked ALS/FTD. By interacting with poly(GR), Kapβ2 significantly improves neuronal survival, underscoring its potential as a therapeutic target to mitigate neurodegeneration. This discovery opens new avenues for research into ALS/FTD treatment strategies focused on enhancing Kapβ2 expression levels.

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Contact us

email: Aaron dot Haeusler at Jefferson dot edu

mail: 900 WALNUT ST, JHN SUITE 410, PHILADELPHIA, PA 19107

Disclaimer: The views expressed in this website may not reflect the views shared by the Weinberg ALS Center, the Sidney Kimmel Medical College, the Vickie and Jack Farber Institute for Neuroscience, nor Thomas Jefferson University.

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