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Aaron Haeusler Lab

Identifying neurodegenerative

mechanisms and interventions for ALS and FTD

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Research

Our lab is driven to understand how molecular mechanisms drive disease in patients with ALS/FTD. Our primary research goal is to identify the molecular cascade of pathogenic events that are initiated in these debilitating diseases in efforts to develop efficacious therapeutic strategies.

Our Latest Publications

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit
Layla Ghaffari et al. 2025. AJP – Cell Physiology

Our recent study using iPSC-derived cortical neurons reveals how neuronal activity drives gene dysregulation in C9ORF72-linked ALS/FTD. We uncover synaptic dysfunction, peroxisomal dysregulation, and NPAS4-linked transcriptional shifts, highlighting key disease-modifying pathways. Explore our research and generate your own discoveries using our interactive dataset included in the link in the article.

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Contact us

email: Aaron dot Haeusler at Jefferson dot edu

mail: 900 WALNUT ST, JHN SUITE 410, PHILADELPHIA, PA 19107

Disclaimer: The views expressed in this website may not reflect the views shared by the Weinberg ALS Center, the Sidney Kimmel Medical College, the Vickie and Jack Farber Institute for Neuroscience, nor Thomas Jefferson University.

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