C9ORF72's Role in Neuroinflammation: New ALS and FTD Insights

Limone F, Couto A, Wang JY, Zhang Y, McCourt B, Huang C, Minkin A, Jani M, McNeer S, Keaney J, Gillet G, Gonzalez RL, Goodman WA, Kadiu I, Eggan K, Burberry A. Myeloid and lymphoid expression of C9orf72 regulates IL-17A signaling in mice. Sci Transl Med. 2024 Jan 31;16(732):eadg7895. doi: 10.1126/scitranslmed.adg7895. Epub 2024 Jan 31. PMID: 38295187.

Summary

This study led by the laboratories of Drs. Aaron Burberry and Kevin Eggan demonstrates the significant role of C9orf72 in regulating IL-17A signaling and neuroinflammation in ALS and FTD. The study, focusing on mouse models, reveals how myeloid and lymphoid expression of C9orf72 influences autoimmune responses, potentially contributing to the onset of neurological symptoms. The findings underscore the importance of C9orf72 in neuroinflammatory pathways, offering new perspectives for understanding and treating ALS and FTD.

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